We estimated the variance in these traits attributable to the loci discovered using data from the KORA-S4 sample (the largest population-based sample within stage 2). The explained variance of WC was estimated to be 0.05% for rs987237 (TFAP2B) and 0.04% for rs7826222 (MSRA). This corresponds to absolute WC effect sizes of 0.49 and 0.43 cm respectively (as estimated across all population based samples in stage 2). The SNP near LYPLAL1 (rs2605100) explains 0.02% of the WHR variance in women (absolute effect size on WHR of 0.0014).
