Heritability estimates based on twin studies (h2=0.37) have indicated that familial aggregation of depression is influenced by additive genetic effects11, and several previous studies have documented a considerable genetic overlap between depression and multiple psychiatric as well as somatic disorders and traits12-17. Despite the substantial heritability of depression and other psychiatric disorders, the potential for translating genetic insights into precision psychiatry has yet to be fulfilled, including demonstrating clinical utility of polygenic risk scores (PRS)18-20.
