Given that Wip1 has a role in tumorigenesis, Wip1 is an attractive chemotherapeutic target. Therefore, full understanding of the regulation of Wip1 expression and characterization of the targets of Wip1 phosphatase activity in specific types of tumors may aid the development of more effective anti-tumor therapies. In conclusion, Wip1 negatively regulates stress responses, such as apoptosis, DNA repair, cell cycle arrest and inflammation, and as a consequence, cooperates with activated oncogenes in promoting tumorigenesis.
