To determine whether CREM relates to impulsivity and addiction vulnerability in humans, we studied CREM genotype in relation to behavior guided by the animal findings. We performed a set of independent, hypothesis-driven association studies focused on a variant within the CREM gene (rs12765063) that was similarly positioned within the CREM locus when compared to the rodent polymorphism (Fig. 2j). This variant was within a conserved region of the promoter, in strong linkage disequilibrium with the surrounding region, and enriched with H3K27Ac and H3K4me3 in the striatum22, all suggesting the presence of adjacent regulatory features (Supplementary Fig. 7).
