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Chunk #19 — RESULTS

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Estimation of significance thresholds for genomewide association scans.
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The half–saturation parameter was estimated as = 1.88 (1.47–2.11), indicating that at about twice the current number of markers, only half the total multiplicity will be accounted for. This does not mean that current marker panels have insufficient coverage, rather that permutation correction based only on typed markers may be too optimistic; we return to this point in the Discussion.