In summary, there are credible arguments for a functional role of the ECS in mood disorders including anxiety and depression. There is also immense interest regarding clinical research in cannabinoids, in part due to the fact that cannabis was declared to be an illicit drug for a long time, hindering its legitimate use in medicine if proven to have benefit. In mood disorders, there is a need for multiple comprehensive RCTs, as the data so far are not completely convincing.
