(P = 0.011). When testing rs7916403 under a recessive mode of genetic effect, an increased OR of 1.39 [95% CI: 1.07 – 1.81] was observed (P = 0.015). For the replication sample, no significant evidence of association with alcohol dependence was found, although the effects remained in the direction of the risk allele: OR of 1.17 [95% CI: 0.95 – 1.15] for an additive genetic effects model (P = 0.15); and OR of 1.36 [95% CI: 0.94 – 1.96] under a recessive model (P = 0.10).
