that there are considerable pleiotropic effects underlying SCZ, bipolar disorder (BiP), and major depressive disorder (MDD)25. By contrasting the SCZ PRS with PRS for genetically correlated disorders, such as BiP and MDD, the specificity and commonality of these genetic vulnerabilities on brain activity can be estimated. Although a previous study reported no association between SCZ PRS and classical EEG endophenotypes (e.g., P3 amplitude)26, no study has examined the influence of SCZ PRS on EEG connectivity in unaffected individuals. Further, no study has examined how these associations may differ by sex or across adolescence and young adulthood, the time-frame during which SCZ typically manifests. This is important, given research demonstrating sex and developmental differences in measures of EEG coherence27,28, the clinical presentation of SCZ29, and polygenic effects on neuropsychiatric illnesses22,30,31.
