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Chunk #20 — RESULTS — Implications based on relationships with other traits

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
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We used LD score regression to estimate rg of major depression with 221 psychiatric disorders, medical diseases, and human traits22,60. Supplementary Table 12 contains the full results, and Table 3 holds the rg values with false discovery rates < 0.01. First, the rg were very high between our major depression GWA results and those from two studies of current depressive symptoms. Both correlations were close to +1 (the samples in one report overlapped partially with this meta-analysis16 but the other did not 14).