distribution than towards the high end of the distribution. Similarly, there is more power to detect low-frequency genetic variants associated with scoring above-average on Neuroticism, compared to scoring below-average. Overall, the phenotypic information content is higher for Neuroticism than for Extraversion in most cohorts, suggesting more power to find loci for Neuroticism than for Extraversion. Combined with the finding of more additive genetic variance in Neuroticism than in Extraversion, we expect that Neuroticism loci will be easier to find than Extraversion loci.
