participated in the project each year, with ∼97% also choosing to participate in the DNA component. The sample is representative of the overall university population in terms of gender and racial/ethnic breakdown. After 4 years of enrolling incoming freshmen, we have over 9,600 students participating in the project. Students are invited to complete a follow-up survey every spring thereafter. Accordingly, the project allows us to understand patterns of substance use and mental health among our students when they start at the university, and the risk and protective factors that impact behavior across their college years (and beyond). For the first cohort, 80% of eligible participants completed the freshman follow-up survey, 59% completed the sophomore follow-up, 53% the junior follow-up, and 45% have completed the senior follow-up (on-going). Students are reminded of spring follow-up surveys via e-mail, mailed information, advertisements around the university and on campus busses, student “recruiters” passing out flyers and manning information tables, dorm visits and educational events. We are currently implementing a number of additional initiatives intended to bolster retention, including feeding back study results to students and enhancing our use of social media to provide a more interactive on-going connection between students and the project.