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Chunk #17 — DISCUSSION

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PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways.
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Recently, we created the SomamiR database (44) as a web-based platform for systematic investigation of the impact of somatic mutations on miRNA dysregulation in cancer. We also found that the integrated analysis of somatic and germ line mutations may provide useful insights on the functional impacts of both types of mutations (45). Therefore, we have created links between the entries of the two databases, allowing users to easily analyze both genetic polymorphisms and somatic mutations in miRNAs and their target sites.