detection. By comparison, MDA yields a high rate of artificial chimeric DNA molecules that can lead to false-positive calls in downstream analyses (79), whereas MALBAC exhibits reduced coverage of certain genomic regions (14, 16, 80), especially those rich in repetitive sequences (78). Considerable advances have recently been made in detecting SNVs (81, 82), CNVs (83), and MEIs (16) in WGA samples; however, best practices necessitate evaluating each WGA approach for the detection of specific types of somatic mosaicism.
