For CHRNA5-CHRNA3-CHRNB4, the most significant SNP was rs1051730 (P=1.1×10−5) mapping in CHRNA3 (Figure-1, Table S2 in Supplement 1). Carriers of rs1051730[A] were at increased risk of being heavy/regular smokers than non-carriers with similar effect-size at age 14 [OR(95%CI):1.27(1.06–1.52)] and 31 years [OR(95%CI):1.28(1.13–1.44)]. As expected(3, 48), carriers of rs1051730[A] were not at increased risk of being light/occasional smokers compared with non-carriers (Table 1)(3).
