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Chunk #4 — Methods — Projects and subjects

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Quality control and quality assurance in genotypic data for genome-wide association studies.
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The GENEVA projects covered in this article are (1) Addiction to alcohol and other drugs, (2) Lung Cancer, (3) Type 2 diabetes (T2D) with subjects from the Nurses’ Health Study (NHS) and (4) T2D with subjects from the Health Professionals Follow-up Study (HPFS). The Addiction and Lung Cancer projects were genotyped on the Illumina Human1Mv1_c and HumanHap550-2v3_B arrays, respectively, at the Center for Inherited Disease Research (CIDR). The T2D projects were genotyped on the Affymetrix Genome-Wide Human 6.0 array at the Broad Institute Center for Genotyping and Analysis (Broad). Details about GENEVA organization, study designs and subjects are described in Supporting Information, on the GENEVA website (see Web Resources), and in Cornelis et al [2010]. Data for these projects, along with QC/QA reports are posted in the NCBI database for Genotypes and Phenotypes [Mailman, et al. 2007] (dbGaP). The QC/QA reports are posted also on the GENEVA web site.