There are striking similarities across these papers by Enoch and Albaugh 6, Matsushita and Higuchi 7, Martinez et al. 8, and Dick et al. 9. Each paper raises concerns about the limited racial/ethnic diversity in genetic study samples, subjects’ often distrust of investigators, and the reluctance of some racial/ethnic groups to participate in genomics research. The history of eugenics and other historical traumas; limited exposure and access to genetic research findings and opportunities to participate in research; the stigma attached to psychiatric disorders; and concerns about privacy, the accuracy of testing, and misuse of information are presented. Although some of these issues can be common across all potential subject pools regardless of race/ethnicity, it is important to consider the differential cultural implications of genetic research for the community/population of interest when planning a study. Several suggestions are offered for future genetic studies. For example, understanding the relevance of genetic findings to the individuals and families in various communities could help increase their motivation to participate, and outreach by investigators to gather community input and to provide better and more relevant information is essential.
