not in either brain tissue), 3) eQTLs common to brain and muscle, and 4) a final partition with non-eQTL SNPs. The last analysis included four total partitions to accommodate eQTLs exclusive to each brain tissue (cerebellum and parietal) as well as eQTLs found in both brain tissues, and the remainder of all imputed SNPs. Annotations were applied to the TS and OCD case/control data and used to create partitions. This resulted in a total of four separate annotation-based REML analyses. For each analysis, we created a single GRM for each partition. Finally, for each analysis, we included the functional variant GRM(s) and the respective complement GRM together in one joint REML analysis.
