than female drinkers (McGue et al., 1992, although see Dick et al., 2007 for an exception). It is speculated that the more robust association between PRS for alcohol dependence and early patterns of heavy episodic drinking in males may be developmentally-driven, and that discrepancies in the literature regarding sex differences in genetic influences for alcohol-related phenotypes may be addressed by controlling for age-of-onset in cross-sectional designs, or by adopting a more developmental approach that accounts for the transition from adolescence into adulthood.
