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Chunk #40 — Discussion

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Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder.
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complete picture of dysfunction across regions and allows for the identification of novel transcripts and signaling pathways that would not otherwise be detected. Furthermore, we demonstrate striking consistency with a previous RNA-sequencing study in disrupted molecular pathways and specific striatal transcripts identified as DEGs, suggesting potential common molecular mechanisms underlying OCD pathogenesis.