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Chunk #73 — Conclusions

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Dosage transmission disequilibrium test (dTDT) for linkage and association detection.
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On the other hand, a major advantage of the TDT is that it is not susceptible to population stratification. The dTDT is, however, sensitive in that it depends on the marker allele frequencies in the population. Because of this reason, when we combine results from both Case-Control and dTDT, the MH test potentially inflates errors due to population stratification. This can be noticed in the Q-Q plot as we present in Figure 7 .