Klf12 is regulated by acute ethanol in mouse brain and is a hub in a network of ethanol-responsive genes (Wolen et al., 2012) including many implicated in ethanol response (e.g. Grm3 (Gass and Olive, 2008), Kcnma1 (Davies et al., 2003) and Gsk3b (French and Heberlein, 2009)). Orthologs of KLF12 (Figure 4D) and its binding partner CTBP1 (Bettinger et al., 2012) are required for the development of AFT in C. elegans. The targets of KLF12 regulation are not yet known, but the convergent evidence argues strongly they are central to acute ethanol response and potentially relevant to AD risk.
