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Chunk #0 — INTRODUCTION

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A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
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Maternal smoking in pregnancy is associated with a number of adverse outcomes including fetal growth restriction and various pregnancy complications (1,2). Clinical trials of interventions to promote smoking cessation have effectively reduced smoking and the prevalence of low birth weight and preterm birth (3), but despite a strong and direct public health message, many pregnant women continue to smoke. In the year 2000, prevalence estimates for the USA, Sweden and UK, were 12, 13 and 20%, respectively (2,4).