Interestingly, some of the results from SCZD patient-derived hiPSCs and neurons are very similar to those of hiPSC model studies in other disorders. For example, SCZD hiPSC-derived neurons also show increased L1 retrotransposition (similar to Rett syndrome) 132, increased tyrosine hydroxylase, and consequent increased catecholamines, dopamine, norepinephrine and epinephrine (similar to Timothy syndrome) 133, potentially hinting at similar pathologies between these neurodevelopmental disorders.
