observed differences in gene expression between striatal subregions. Genes that were differentially expressed between OCD subjects and unaffected comparison subjects in this study were also enriched for synaptic and immune function protein-encoding transcripts37. However, this study only examined the striatum and not its key glutamatergic input, the cortex. Here we used unbiased RNA sequencing to examine the transcriptome of two orbitofrontal cortex (medial and lateral OFC) and two striatal subregions (caudate and nucleus accumbens) in OCD subjects and unaffected comparison subjects.
