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Chunk #9 — 1. Introduction — 1.3. ERP old/new effects in schizophrenia

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Stimulus- and response-locked neuronal generator patterns of auditory and visual word recognition memory in schizophrenia.
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Recording 9-channel ERPs with a linked-mastoids reference during a study-test paired-associate word learning task, Baving et al. (2000) found reduced old/new effects for 16 schizophrenic patients compared with 16 healthy controls, which overlapped a P2 followed by a positive slow wave (SW), and larger P2 old/new effects correlated with greater recognition accuracy in controls. Although patients performed more poorly, there were no group differences in overall amplitudes of P2 and positive SW, and old/new effects in controls were rather small. Using a study-test word recognition task combined with a Remember/Know procedure to disentangle recollection- and familiarity-based retrieval processes, Tendolkar et al. (2002) reported left-parietal and right-frontal recollection (Remember) old/new effects for both 14 schizophrenic patients and 14 healthy controls, but these effects extended over a longer time interval in controls. Although more robust Remember old/new effects were evident for both groups at mid-centroparietal sites, ERP analysis was restricted to four medial-lateral electrode pairs despite the use of 28-channel EEG montage with an average reference. In contrast, familiarity (Know) old/new effects were observed for patients over frontal sites beyond 500 ms,