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Chunk #23 — Results — Polygenic score analyses

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Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.
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as opioid use disorder criteria count, conduct disorder and antisocial personality disorder criteria count, lifetime history of arrest or incarceration, and lifetime history of being fired from work – were not included in our Genomic SEM analyses. The associations between the EXT polygenic score and this broad range of phenotypes represents an affirmative test of the hypothesis that genetic variants associated with externalizing liability generalize to a variety of behavioral and social outcomes related to self-regulation.