Alcohol-dependent disorders have been extensively studied in rodents but the human disorder is not fully mimicked by these models (Crabbe et al., 2013). A few studies have been conducted on post-mortem brain samples from alcoholics (Lewohl et al., 1997, 2001; Dodd and Lewohl, 1998; Buckley et al., 2000, 2006; Mayfield et al., 2002; Buckley and Dodd, 2004; Dodd et al., 2004; Flatscher-Bader et al., 2005, 2006; Kalsi et al., 2009; Jin et al., 2011a, 2014a,b; Domart et al., 2012). These studies are very valuable as they aid in the understanding of the mechanism underlying human alcohol dependence.
