Chunk #25 — Results — Widespread effects of cocaine and withdrawal on catecholaminergic, GABAergic, cholinergic, glutamatergic, and endocannabinoid pathways
The endocannabinoid system is heavily involved in many reward-seeking responses to drugs of abuse (Orio et al., 2009). Levels of transcripts encoding Cnr1 (the CB1 endocannabinoid receptor) and the cannabinoid synthetic enzymes Dagla and Napepld showed sustained increases in Cocaine and Withdrawal, while Daglb showed a sustained decrease (Figure 8). The effect of Cocaine expression on each of these genes was confirmed by qPCR analysis of two separate sets of animals.
