For associations identified by the COGA project, after correction for multiple testing, we found no SNPs or tagging SNPs that confirmed associations reported for alcohol dependence diagnosis. For BBX, we found 9 SNPs that show association with one or more alcohol consumption measures, particularly rs1403774 (heaviest period drinks per drinking day, p=9.5E-5; current drinks per drinking day, p=1.2E-4); rs2049339 (HOD, p=4.7E-3; heaviest period drink per week, p=3.6E-4); and rs9875732 (heaviest period drinks per week, p=6.6E-4; drinks per drinking day, p=4.6E-4); with only this last SNP associated with AUD-FS (p=7.9E-4) and with AD-FS (p=4.5E-3). One of these, rs2049339, was in weak LD with the COGA SNP (rs10511260: r2=.20, D′=.57), with the two others having r2<.05. No SNPs or tagging SNPs confirmed in the German Alcoholism GWAS study were replicated in our analyses, nor were any SNPs or tagging SNPs identified as the most strongly associated SNPs in the SAGE study.
