Allele frequencies in both samples were very similar across GABRG1 however they began to differ in the intergenic region and differed markedly in GABRA2 (Table 1). In both the Plains Indians and the Finns, GABRG1 SNPs extending from intron 1 to downstream from the 3′ UTR region were significantly associated with AUD (Table 1). In the Finns, SNPs in the GABRG1 promoter and the intergenic region between GABRG1 and GABRA2 were also associated with AUD. The allelic associations were in the same direction in both samples.
