the MEK inhibitor U0126.51 Even in the absence of BDNF infusion, U0126 injections into the central amygdala decrease drug seeking during cocaine withdrawal,47 indicating that ERK activity in the central amygdala is required for drug-seeking during cocaine withdrawal.47 This requirement is specific for cue-induced cocaine seeking but not for reinforced responding. Microinjection of U0126 into the amygdala does not reduce self-administration of cocaine or consumption of palatable foods.47
