Chunk #24 — RESULTS — Phenotypic variation accounted for by testing genetic factors

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Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.

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Nagelkerke’s adjusted R2 was used to assess the proportion of nicotine dependence variation explained by individual SNPs and multivariable models in the primary sample (Table 3). The overall phenotypic variance explained by the genetic variants in this one gene was 2.4% in European Americans and 1.0% in African Americans.