Chunk #26 — Materials and methods — Polygenic profiling analysis

Source

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.

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In UKB, the association between PGS and MDD, rMDD, fMDD, and mMDD was tested in a generalized linear model framework by regressing the PGS onto the phenotype, covarying for assessment centre, genotype array and batch and the first eight PCs.