One of the major goals of using iPSCs for personalized medicine and disease modeling is to generate therapeutically target cells such as functional neurons of specialized neurotransmitter phenotype. We have previously shown that several hESC lines differentiate efficiently and similarly into authentic dopaminergic neurons using our xeno-free defined protocol [5], and therefore, we wish to address whether iPSC-derived NSCs can differentiate into functional dopaminergic neurons using an identical protocol.
