Chunk #19 — Results

Source

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.

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yes

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557 (7%)2446 (9%)36 780 (11%)6394 (9% [87 g/week vs 98 g/week]‡)>100–≤150 g per week36 236 (15%)2602 (10%)55 815 (17%)10 051 (14% [126 g/week vs 126 g/week]‡)>150–≤250 g per week31 645 (13%)3090 (12%)60 025 (18%)12 255 (17% [193 g/week vs 173 g/week]‡)>250–≤350 g per week23 607 (10%)1744 (7%)26 669 (8%)6927 (10% [303 g/week vs 248 g/week]‡)≥350 g per week25 432 (10%)1796 (7%)25 201 (8%)7396 (10% [515 g/week vs 354 g/week]‡)Baseline characteristics restricted to all current drinkersAlcohol consumption (g/week), median (5th–95th percentiles)87·7 (2·2–522·4)61·9 (2·6–404·0)103·9 (11·8–420·8)105·2 (6·0–482·8)Age (years) at baseline57·1 (8·7)55·0 (9·2)56·5 (8·0)55·3 (8·2)SexMale162 685 (66%)13 508 (52%)157 809 (48%)44 360 (62%)Female84 819 (34%)12 528 (48%)168 563 (52%)26 651 (38%)Smoking statusNot current161 037 (65%)17 608 (68%)293 182 (90%)50 930 (72%)Current86 467 (35%)8428 (32%)33 190 (10%)20 081 (28%)History of diabetesNo237 685 (96%)24 875 (96%)315 090 (97%)68 159 (96%)Yes9819 (4%)1161 (4%)11 282 (3%)2852 (4%)BMI, kg/m226·1 (3·8)26·4 (4·1)27·0 (4·4)26·1 (3·8)HDL-C, mmol/L1·40 (0·41)1·40 (0·42)Not available*1·41 (0·41)Total cholesterol, mmol/L5·80 (1·17)6·11 (1·16)Not available*5·78 (1·08)Systolic blood pressure, mm Hg136·5 (19·0)138·4 (21·3)137·9 (18·5)134·6 (18·4)Major outcomes restricted to current drinkersAll-cause mortality events32 813784†67206912All cardiovascular disease18 79112 758746911 597Data are n, n (%), or mean (SD), unless otherwise indicated. ERFC=Emerging Risk Factors Collaboration. EPIC-CVD=European Prospective Investigation into Cancer and Nutrition—Cardiovascular Disease. BMI=body-mass index.