The findings reported here by the CommonMind Consortium (CMC) represent a unique resource to understand brain function, basic neuroscience, and brain diseases at the molecular level. They include a comprehensive compilation of gene expression patterns, together with intensive evaluation of eQTLs across the genome. The expertise and support to produce and analyze these data required a consortium of brain banks, pharmaceutical companies, a foundation, academic centers, and the NIMH, and this work represents the first phase of our ongoing project. All results are available through the CommonMind Knowledge Portal with a searchable database of eQTLs and other visualizations (https://shiny.synapse.org/users/ssiebert/cmc_eqtl_query/). Both alone, and in combination with other datasets such as GTEx, the CMC data will empower future studies paving the way for connecting genetic influences on cellular function with changes in macroscopic circuits of the brain that may ultimately lead to disease.
