All statistics were performed in MATLAB (vR2017b). When comparing the demographics and the cognitive scores for AD, MCI, and HC, we performed one-way ANOVAs, and t-tests were used to compare AD and HC, AD and MCI, and MCI and HC. The t-tests were used when comparing baseline demographics, cognitive test scores, and CSF measurements for pMCI and sMCI and for comparing baseline and 2nd-year follow-up for HC, MCI, and AD.