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Chunk #9 — Transcriptome analysis: Bulk and single cell

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Comprehensive functional genomic resource and integrative model for the human brain.
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We identified cell fraction changes associated with different traits (Fig. 2E and figs. S14 to S17). For example, particular types of excitatory and inhibitory neurons (such as In6) are present different fractions in male and female samples (Fig. 2E). Also, in individuals with ASD, the fraction of Ex5 was higher and that of oligodendrocytes, lower, with some commensurate increase for microglia and astrocytes (Fig. 2E and fig. S18) (24, 29).