Although most GENEVA studies include persons of European-ancestry, the Alcohol Dependence, Coronary Heart Disease, Prostate Cancer, Birth weight/Maternal Glycemia, Premature Birth and Ischemic Stroke studies have large proportions of subjects of African descent. A significant number of Hispanics and/or Asians are also included in the Oral Clefts and Prostate Cancer studies. These study samples will enable sufficiently powered investigations of non-European-ancestral populations who have been under-represented in published GWAS.