A genome-wide association study (GWAS) from the CONVERGE consortium identified two genome-wide significant loci (chromosome 10q21.3 and 10q26.13) using a severe depressive phenotype (5053 cases and 5337 controls) in female Han Chinese individuals, treated in a hospital setting6. A subsequent study by the Psychiatric Genomics Consortium (PGC) stratified the PGC MDD mega-analysis sample2 by age of onset and identified a risk conferring locus at chromosome 3q27.2 in individuals with onset after 27 years of age9.
