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Chunk #9 — Methods and Materials — Mediation/Moderation Modeling

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The AVPR1A gene and substance use disorders: association, replication, and functional evidence.
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We applied several approaches to modeling the factor structure of the FAM: all 41 items were specified as indicators of a single latent factor; a second order factor model with the 41 items indicating seven latent factors (with items grouped according to the theoretical scales of the original measure) loading to a single latent FAM factor; and seven FAM subscale sum scores indicating a single latent FAM variable. In each case, model fit was excellent, and the standardized coefficients for the paths describing the relationships between the measured variables (a, b, and c′ paths in classic mediation modeling [29]) across the models were nearly identical.