Although all the associations indicated in this study were not significant after correction for multiple testing and could have occurred by chance, some of them corroborate reported associations with alcohol and drug addiction as well as other related disorders. The DRD1 SNP rs5326, from this study is in strong LD (D' = 0.93) with the functional 3' UTR SNP rs686 that was associated with nicotine dependence in AA sample (Huang et al., 2008). The dopamine receptor D1 mediates many of the reinforcing and dependence producing properties of drugs (Koob, 1992), and DRD1 SNPs were associated with compulsive addictive behaviors, sensation seeking in alcohol dependents, and smoking (Comings et al., 1997, Kim et al., 2007, Limosin et al., 2003). The association of ADH7 SNP rs971074 in this study is in concordance with the results of Luo et al. for substance dependence and personality traits (Luo et al., 2006, 2007a, b) and may be related to the role of ADH enzymes in the development and maintenance of the dopaminergic system (Chambon, 1993). The 5' UTR AVPR1A SNP rs3759292, indicated in this study,
