genes into clusters under different conditions (i.e., allowing for "biclusters") where different samples' contributions to the given cluster may vary. Since inexpensive genotyping platforms can presently interrogate >1 million SNPs and we are rapidly shifting into the era of whole genome sequencing, existing genetics and systems biology methods would be nicely complemented by computationally feasible, agnostic approaches to the detection of trans-acting factors that regulate groups of genes.
