Here, we present an analysis of more than 270,000 SNPs, genotyped with the Illumina 318K/370CNV chips, on 3,112 individuals across 16 European countries (comprising 19 different samples). Our focus has been on the Baltic region and Eastern Europe since these regions have not been studied in much detail before. The results suggest that geographically adjacent populations overlap partly according to the PC analysis forming four subgroups. Consideration of the inflation factor lambda (λ) [19] further indicates that the loss of power would be minimal when performing and adjusting genetic association studies within these groups.