co-expressed with another splicing variant, SCN8A, a sodium channel alpha subunit expressed within neuronal synapses (Farris and Mayfield, 2014; Schaller and Caldwell, 2000). Although the positive co-expression of SCN4B and SCN8A splice variants may signify their functional importance, this is difficult to predict because there have been few large-scale studies on the role of alternative splicing in alcohol consumption (Lee et al., 2014).