novel environment (Lu et al., 2002), and heightened reactivity to novel situations has been used as a measure of impulsivity and a putative drug abuse liability indicator (Lu et al., 2002; Stoffel and Cunningham, 2008). Narp knockout decreased cocaine-mediated reinforcement and time spent in the center of an open field (Pacchioni et al., 2009). Thus, psychostimulant-induced changes in Narp can augment AMPAR function and individuals with higher Narp may also exhibit higher drug abuse liability.
