As described earlier, gastrectomy was originaly used as a model to attempt to pinpoint the site of alcohol FPM. In 1989, Caballeria and collaborators demonstrated that total of partial gastrectomy, performed for stomach cancer or peptic ulcer disease, virtually eliminated FPM. After oral dosing, men reached BAC to those seen with intravenous administration (91). The fact that these patients were at higher risk of developing AUD after undergoing gastrectomy (238–241) suggests a biological mechanism linking stomach resection with alcohol misuse that is independent of patients having severe obesity, and challenges the common interpretation that AUD post-bariatric surgery is simply a case of “addiction transfer” (242).
