Fixed effects meta-analyses were conducted using the inverse variance-weighted method implemented in METAL39. Study-specific GWAS results as well as GWAS meta-analysis results were corrected for genomic control using all SNPs40. Study-specific Metabochip results as well as Metabochip meta-analysis results were genomic-control-corrected using 4,425 SNPs included on Metabochip for replication of associations with QT-interval, a phenotype not correlated with BMI, after pruning of SNPs within 500 kb of an anthropometry replication SNP. The final meta-analysis combined the genomic-control-corrected GWAS and Metabochip meta-analysis results.
