Given the observed upregulation of miR-34a expression, we next aimed to identify miR-34a targets potentially relevant to the pathogenesis of BD through consideration of genetic risk factors recently identified by recent, large-scale, BD genome-wide association studies (GWAS) by the Psychiatric GWAS Consortium16. Using in silico analysis34, we identified 25 overlapping miR-34a targets predicted by at least four different algorithms (Table 1).
