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Chunk #42 — Discussion

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MAGMA: generalized gene-set analysis of GWAS data.
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MAGMA was also found to be generally much faster than other methods, even methods that used only summary statistics rather than raw data. This is primarily due to the choice of statistical model, which did not require the kind of computationally expensive permutation or sampling procedures used in the other methods. However, even the permutation-based SNP-wise models implemented in MAGMA outperformed their equivalents in other software and yielded very reasonable computation times.